SC25 BoF

Why this BoF matters

Autonomous science is rapidly transforming discovery across materials, energy, climate, and health. Yet most autonomous laboratories still operate in isolation. This BoF convenes researchers, facility operators, and industry partners to connect autonomous capabilities into a cohesive, interoperable ecosystem.

We will explore how HPC can serve as a decision-support platform that enables near real-time coordination of scientific activities, and how intelligent agents can synthesize data from distributed instruments, run predictive models, and adaptively refine experiments.

Agentic AI HPC orchestration Interoperability Provenance

Discussion themes

What APIs and standards are still missing for lab interoperability?
How do we co-schedule agents, instruments, and HPC workflows?
What trust and verification models enable autonomous decision-making?

Agenda

12:15pm CST

Opening Remarks

12:20pm CST

Lightning Talks

A Community Roadmap for Interconnected Autonomous Science Laboratories for Accelerated Discovery
Rafael Ferreira da Silva, ORNL

Enabling Autonomous Labs: The National Science Data Fabric (NSDF) - ORNL Partnership for Real-Time Scientific Discovery
Michela Taufer, UTK

Digital Twins: A critical component in the Autonomous Workflow Development and Operation
Tom Gibbs, NVIDIA

The New Engines of Discovery: Physical Platforms for the Autonomous Scientific Age
Ian T. Foster, ANL

From Simulation to Experiment: The New Era of Agentic AI-Driven Science
Joe Tostenrude, Microsoft

Modular Autonomous for Discovery for Science - Infrastructure for Laboratory Autonomy
Noah Paulson, ANL

1:00pm CST

Open Discussions

St. Louis, MO, USA

Date: November 19, 2025
Time: 12:15pm-1:15pm
Room: Room 131

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